Histologic typing of liver tumors of the rat



Publisher: National Cancer Institute, National Institutes of Health in Bethesda, Md

Written in English
Published: Pages: 206 Downloads: 673
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Subjects:

  • Rats -- Diseases -- United States,
  • Liver -- Tumors,
  • Veterinary histology

Edition Notes

StatementInstitute of Laboratory Animal Resources, National Research Council, National Academy of Sciences.
SeriesNIH publication -- no. 80-13., JNCI -- vol. 64, no. 1., Journal of the National Cancer Institute -- vol. 64, no. 1.
ContributionsInstitute of Laboratory Animal Resources (U.S.)
The Physical Object
Paginationp. 179-206 :
Number of Pages206
ID Numbers
Open LibraryOL17451010M
OCLC/WorldCa9352228

  GST-P (the rat enzyme equivalent to human GST-π) was first found in placenta, but later also in kidney, lung and testis. Recently, it has been shown by Northern blot and Dot blot analysis that GST-P mRNA is present abundantly in preneoplastic lesions and hepatocellular carcinoma induced by genotoxic carcinogen. However, in hepatic preneoplastic lesions, which cell type has GST-P mRNA . This presentations is focused on microscopic features of rat and mouse neoplastic liver lesions that are commonly seen during toxicologic pathology evaluation of rat and mouse two-year cancer bioassays. Rodent Liver Neoplasia View as PDF. Ito Cell Tumor in a Rat Histiocytic sarcoma • Single or multicentric nodules composed of uniform.   Histological typing of tumors of the liver 2nd ed. Berlin, Germany: Springer, ; Google Scholar; 11 Edmondson HA, Steiner PE. Primary carcinoma of the liver: a study of cases among necropsies. Cancer ; Crossref, Medline, Google Scholar; 12 Ishak KG, Goodman ZD, Stocker JT.   Breast cancer is one of the most common cancers in the world. It accounts for over % of all cancers, with reported incidence of about million cases in [1].

  Normal Liver Anatomy. Important! Dual blood supply. Blood exits through the hepatic veins and dumps into the IVC. The vascular supply is important for anatomy, because that's how surgeons decide to resect parts of the liver. They divide up the segments of the liver:\r1 = caudate\r = left lobe \r = right lobe\r. Introduction. Primary hepatocellular carcinoma (HCC) is the fifth most common cancer in the world and the third most frequent cancer-related cause of death with increasing incidence worldwide 1, 2, 3, addition, HCC is the most common primary liver malignancy in the world 5, 6, the majority of cases, it is associated with hepatitis B or C viral infections, aflatoxicosis, and/or liver. One tumor measured 8 cm in diameter (rat 2), and the other tumor measured 4 cm in diameter (rat 3). Each tumor was solid, white, and firm and infiltrated the surrounding soft tissues, including adjacent abdominal wall or thoracic cage. Metastatic deposits were seen at autopsy in the liver and lungs in rats 3 and 4. Light microscopy.   Importantly, the Ki index should be assessed both for primary tumors and for lymph or liver metastases from surgical specimens, because patient survival is most accurately predicted from the highest grade seen at any site. 48 Small bowel NETs are staged according to the American Joint Committee on Cancer staging system (Tables 1 and 2).

The ultrastructure and histology of cholangiocellular carcinomas from feral English sole (Parophrys vetulus) living in polluted waterways of Puget Sound, WA. are described. Electron microscopy confirmed that biliary epithelial cells were the main proliferative cell type composing this variety of neoplasm. Compare Rat Liver Tissue from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more. However, others suggest that liver adenomas and carcinomas are biologically distinct tumor types and combining them may be inappropriate (Butler, ). For example, there is evidence that, in contrast to carcinomas, benign tumors of the rat liver may regress after the cessation of chemical treatment (McConnell et al, Butler, ). Some. Nonalcoholic fatty liver disease (NAFLD) represents one of the most common forms of liver disease worldwide, and it is always regarded as a consequence of a sedentary, food-abundant lifestyle, sitting for an extended time, and a low physical activity level, which often coincide with chronic and long-lasting psychological stress. A Chinese medicine Sinisan (SNS) may be a potential formula for.

Histologic typing of liver tumors of the rat Download PDF EPUB FB2

J Natl Cancer Inst. Jan;64(1) Histologic typing of liver tumors of the rat. Institute of Laboratory Animal Resources, National Research Council, National Academy of. The second edition of this book is devoted entirely to the liver. It is much more comprehensive than the previous edition published 16 years ago, and includes three times as many illustrations as well as the "TNM classification of tumors of the liver".

Journal: Journal of the National Cancer Institute[/01] Histologic typing of liver tumors of the rat. Institute of Laboratory Animal Resources, National Research Council, National Academy of Sciences, Washington, D.C.

Histological typing of tumours of the liver. Berlin ; New York: Springer-Verlag, © (OCoLC) Online version: Ishak, Kamal G., Histological typing of tumours of the liver. Berlin ; New York: Springer-Verlag, © (OCoLC) Document Type: Book: All Authors / Contributors: Kamal G Ishak; Peter P Anthony; L H Sobin; J B.

Williams GM () The pathogenesis of rat liver cancer caused by chemical carcinogens. Biochim Biophys Acta – PubMed Google Scholar Williams GM, Watanabe K () Quantitative kinetics of development of Nfluorenylacetamide-induced, altered (hyperplastic) hepatocellular foci resistant to iron accumulation and of their reversion or persistence following removal of by: 2.

search Council () Histologic typing of liver tumors of the rat. JNCI Popper H, Selikoff IJ, Maltoni C, Squire RA, Thomas LB () Comparison of neoplastic hepatic lesions in man and experimental animals. In: Hiatt HH, Watson JD, Winsten JA (eds) Origins of human cancer, vol 4, book.

The liver, exocrine pancreas, and major salivary glands are accessory digestive organs. The rat liver is immature at birth but by all hepatic cords are one-cell layer thick and bile ductules are formed. Extramedullary hematopoiesis (EMH) is very prominent until and thereafter diminishes dramatically by PND The rat mammary gland has been studied extensively as a model for cancer.

Factors such as the strain of rat, age, parity, hormones, and diet must all be considered in the proper interpretation of apparent increases in mammary gland neoplasms following exposure to.

Stewart HL, Williams G, Keysser CH, Lombard LS, Montali RJ () Histologic typing of liver tumors of the rat. J Natl Cancer Inct – Google Scholar Sugihara S, Kojiro M () Pathology of cholangiocarcinoma. Histologic typing of liver tumors of the rat.

J Natl Cancer Inst64, Google Scholar. Stinson, S.F., Hoover, K.L., and Ward, J.M. Quantitation of differences between spontaneous and induced liver tumors in mice with an automated image analyzer.

Cancer Lett14. Comparative liver macroanatomy •Human – Lobes: Right, left, caudate, quadrate – Majority of liver on R side cranial abdomen – Subdivided into 9 discrete units based on vasculoductular supply - important in surgery • Rodent – Lobes: Right, left, median, caudate – More evenly spaced across cranial abdomen – Rats lack gallbladder.

Telling It Like It Is: 23 Breast Cancer Journeys; Pretty Is What Changes: Impossible Choices, the Breast Cancer Gene and How I Defied My Destiny; Histological Typing of Cancer and Precancer of the Oral Mucosa; Additional resources for The LEC Rat: A New Model for Hepatitis and Liver Cancer.

Chemoprevention of Rat Liver Carcinogenesis by S-Adenosyl-l-methionine: A Long-Term Study. October ; Stewart, H. L., et al. Histological typing of liver tumors of the rat. Institute. “Histologic typing of liver tumors of the rat,” J. Natl. Cancer Inst.,64, (). Miyake, J.

Gaylor, and H. Morris, J. Biol. Chem., (). Paraffin blocks of rat cases obtained from the National Toxicology Program (NTP) archives were from studies of chemical-induced liver tumors and represent diagnoses peer reviewed by experienced rodent toxicologic pathologists.

Rat cases include HCCs, HCAs and basophilic, eosinophilic and clear cell foci of cellular alteration (FCAs). 1 found the book competently written, well researched and very informative.

It is a pleasure to study the monograph and it is a valuable publication to have for anybody working with rat tumors. As I stated in a previous book review (International Histological Classification of. Histologic typing of liver tumors of the rat.

JNCI ; Auf G, Ghanadian R. Analysis of androgen receptors in the human prostate by isoelectric focusing in polyacrylamide gel.

J Steroid Biochem ; Randall VA, Mainwaring WIP. Preliminary investigations of a new radioligand, 3 H-mibolerone for use in androgen. There is an urgent need to integrate these facets of diagnosis into cancer classification internationally, and to update the WHO Classification of Tumours on a regular basis.

IARC has been responsible for the WHO Classification of Tumours, also known as the WHO Blue Books, since the 3rd edition (–), which covered all organ sites in Cancer Lett.

Feb; 4 (2)– Histologic typing of liver tumors of the rat. Institute of Laboratory Animal Resources, National Research Council, National Academy of Sciences, Washington, D.C. J Natl Cancer Inst. Jan; 64 (1)– Barnes WS, Lovelette CA, Tong C, Williams GM, Weisburger JH. He, Nathan D.

Price, Genome-scale metabolic model of the rat liver predicts effects of diet restriction, Scientific Reports, /s, 9, 1, (). Crossref Diseases of the Liver and Biliary System in Children, Fourth Edition. The histology and electron microscopic ultrastructure of the chemically induced liver HCC in this study resembled human HCC with a cirrhosis background.

An immunohistochemistry study confirmed that the tumors were of hepatocyte origin. All highly, moderately, and poorly differentiated HCC tumors were identified in this study. Histologic typing of liver tumors of the rat. Institute of Laboratory Animal Resources, National Research Council, National Academy of Sciences, Washington, D.C.

J Natl Cancer. The WHO Classification of Head and Neck Tumours is the ninth volume in the 4th Edition of the WHO series on histological and genetic typing of human tumors. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies.

Histologic typing of liver tumors of the rat. Natl. Cancer Insti. Google Scholar | Medline. Svoboda DJ and Reddy JK (). Lasiocarpine-induced transplantable squamous cell carcinoma of the rat skin. Natl. Cancer Insti. Index of Slides. Liver Carcinogenesis and Use of Rat and Mouse Models R.R. Maronpot [email protected] 2.

Global Importance of Liver Cancer • 6th most common cancer type worldwide – 3rd most common cause of cancer death worldwide •new liver cancer cases in –liver cancer related deaths – % hepatocellular carcinoma – Highest incidence in Asia and sub.

Histological typing of breast tumours, by R. Scarff and H. Tortoni (t) No. Histological typing of soft tissue tumours, by F.

Enzinger in collaboration with R. Lattes and H. Tortoni () No. Histological typing of oral and oropharyngeal tumours. Cancer Letters, 30 () 49 Elsevier Scientific Publishers Ireland Ltd. INHIBITORY EFFECT OF CHLOROGENIC ACID ON METHYLAZOXYMETHANOL ACETATE-INDUCED CARCINOGENESIS IN LARGE INTESTINE AND LIVER OF HAMSTERS HIDEKI MORI*, TAKUJI TANAKA, HIROTO SHIMA, TOKURO KUNIYASU and MASAYOSHI TAKAHASHI.

Hypertrophy and Liver Cancer in Mice – enzyme induction > % – liver weight >% at 1 year – induction of p enzymes may lead to the formation of oxygen radicals or other electrophilic reactive species capable of causing DNA damage – hyperplasia and degeneration – polyploidy, aneuploidy – high probability of liver cancer at 2 years.

Consistent liver metastases in animal models is generally observed only with certain cancer cell lines. With the aim of improving on existing animal models of liver metastases, we hypothesized that cancer cells encased in μm microcapsules, mimicking micrometastatic foci, might be effective seeds of liver metastases.

A total of 3, microcapsules, containing to 1, viable cells. Although liver cancer arises frequently in the course of genetic hemochromatosis (GH), it has not been previously studied in a large series of patients with well-defined GH.: The bioclinical and pathological data from 1 cholangiocarcinoma and 53 hepatocellular carcinomas (HCCs) complicating GH in 32 untreated and 22 de-ironed patients are reported.

Book. Full-text available. Jan ; Wolf-Dieter Kuhlmann; View. 'Histologic Typing of Liver Tumors of the Rat' is designed to provide uniform categorization of tumors. The purpose is to. Williams G. M. () Liver carcinogenesis: the role for some chemicals of an epigenetic mechanism of liver tumor promotion involving modification of the cell membrane.

Fd Cosmet. Toxicol. 19, Williams G. M. () Phenotypic properties of preneoplastic rat liver lesions and applications to detection of carcinogens and tumor promoters.WHO Classification of Tumours of the Digestive System is the third volume of the 4th Edition of the WHO series on histological and genetic typing of human tumors.

This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies monitoring response to therapy and clinical outcome.